MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response

More on goals and impact

Focus on human microbiome

MICROB-PREDICT will investigate the human microbiome to identify predictors and mechanisms associated with the development of decompensation of cirrhosis and progression to acute-on-chronic liver failure (ACLF) and death.

Project duration

6 ¼ years

Grant amount

15 million €

10 countries

22 partners

Start

1st January 2019

Main goals:

  • Integration of existing clinical, laboratory, microbiome and multi-omics data from 12 cohorts, combining more than 200,000 data points from more than 10,000 subjects
  • Development of microbiome-based tests for better stratification of cirrhosis patients leading to personalized prediction and prevention of decompensation and ACLF and more personalized allocation to treatment
  • Validation of new microbiome-based markers in a clinical trial to enable prediction of response and thereby optimization of rifaximin or albumin treatment
  • Design of modern, effective nanobiosensors as useful clinical tools to set the foundation for personalized therapy
  • Involvement of world-leading microbiome specialists, technology leaders and clinical experts for scientific excellence, the European Liver Patients Association (ELPA) and the European Association for the study of the Liver (EASL)

Impact:

  • Improved specificity of diagnostic tools
  • Better prediction and thereby prevention of decompensation and ACLF
  • Stratifying and personalizing the treatment of decompensated liver cirrhosis and ACLF
  • Increasing survival and decreasing health care burden
  • Novel diagnostic and therapeutic approaches to stimulate innovation in the European healthcare industry

Press briefing

31.01.2019, 10.30h
European Foundation For the Study of Chronic Liver Failure
Travessera de Gràcia,11, 7th floor
08021 Barcelona

Coordination

European Foundation For the Study of Chronic Liver Failure
Prof. Dr. Jonel Trebicka
Travessera de Gràcia, 11, 7th floor
08021 Barcelona, Spain

Project management

concentris research management GmbH
Dr. Ameli Schwalber
Fürstenfeldbruck, Germany

Phone: +49 8141 62528571
Email: info@microb-predict.eu

Partners

MICROB-PREDICT unites the expertise from 22 different European partners (hospitals, research foundations and institutes, patient and physician associations, and small-and-medium-sized enterprises, SMEs) to accomplish its aims.